4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Base Information

Chemical Name:4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
CAS No.:1362818-35-6
Molecular Formula:C₂₄H₂₄BrN₃O₃
Molecular Weight:482.377
Hs Code.:

Synonyms:4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

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Chemical Property of 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Chemical Property:

Purity/Quality:

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Technology Process of 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

There total 12 articles about 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1362820-19-6
4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

: 1362818-35-6
4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 5h;

Reference yield:

: 60710-39-6
3-bromo-p-cresol

: 1362818-35-6
4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1 h / 60 °C

1.2: 0.67 h / 180 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydroxide; bromine; water / 1,4-dioxane / 1.17 h / 0 - 20 °C

3.2: pH 2

4.1: trifluoroacetic acid; methyl-phenyl-thioether / toluene / 18 h

5.1: thionyl chloride / 72 h / 50 °C

6.1: pyridine / 1 h

7.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

8.1: triethylamine / acetone / 1 h

9.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

11.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

12.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h / 50 °C

With pyridine; N-Bromosuccinimide; thionyl chloride; methyl-phenyl-thioether; water; bromine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1-(4-bromo-2-hydroxy-5-methylphenyl)ethan-1-one

: 1362818-35-6
4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydroxide; bromine; water / 1,4-dioxane / 1.17 h / 0 - 20 °C

2.2: pH 2

3.1: trifluoroacetic acid; methyl-phenyl-thioether / toluene / 18 h

4.1: thionyl chloride / 72 h / 50 °C

5.1: pyridine / 1 h

6.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

7.1: triethylamine / acetone / 1 h

8.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

10.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

11.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h / 50 °C

With pyridine; N-Bromosuccinimide; thionyl chloride; methyl-phenyl-thioether; water; bromine; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; acetone; toluene;