4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

Base Information

Chemical Name:4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid
CAS No.:1362820-19-6
Molecular Formula:C₁₉H₂₀BrNO₄
Molecular Weight:406.276
Hs Code.:

Synonyms:4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

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Chemical Property of 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

Chemical Property:

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Technology Process of 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

There total 11 articles about 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1362820-16-3
phenylmethyl 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoate

: 1362820-19-6
4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

Guidance literature:: phenylmethyl 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoate; With water; lithium hydroxide; In tetrahydrofuran; at 40 ℃;

With hydrogenchloride; In tetrahydrofuran;

Reference yield:

: 60710-39-6
3-bromo-p-cresol

: 1362820-19-6
4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1 h / 60 °C

1.2: 0.67 h / 180 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydroxide; bromine; water / 1,4-dioxane / 1.17 h / 0 - 20 °C

3.2: pH 2

4.1: trifluoroacetic acid; methyl-phenyl-thioether / toluene / 18 h

5.1: thionyl chloride / 72 h / 50 °C

6.1: pyridine / 1 h

7.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

8.1: triethylamine / acetone / 1 h

9.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

11.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

With pyridine; N-Bromosuccinimide; thionyl chloride; methyl-phenyl-thioether; water; bromine; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1-(4-bromo-2-hydroxy-5-methylphenyl)ethan-1-one

: 1362820-19-6
4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydroxide; bromine; water / 1,4-dioxane / 1.17 h / 0 - 20 °C

2.2: pH 2

3.1: trifluoroacetic acid; methyl-phenyl-thioether / toluene / 18 h

4.1: thionyl chloride / 72 h / 50 °C

5.1: pyridine / 1 h

6.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 85 °C

7.1: triethylamine / acetone / 1 h

8.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

10.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

With pyridine; N-Bromosuccinimide; thionyl chloride; methyl-phenyl-thioether; water; bromine; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; acetone; toluene;