N-(3-chlorophenyl)-2-methyl-propanamide

Base Information

• Chemical Name: N-(3-chlorophenyl)-2-methyl-propanamide
• CAS No.: 7017-17-6
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Mol file: 7017-17-6.mol

Synonyms:3-Chlor-N-isobutyryl-anilin;N-Isobutyryl-m-chlor-anilin;m-chloro isobutyranilide;

Chemical Property of N-(3-chlorophenyl)-2-methyl-propanamide

Chemical Property:

• Vapor Pressure: 6.81E-05mmHg at 25°C
• Boiling Point: 343.9°Cat760mmHg
• Flash Point: 161.8°C
• PSA: 29.10000
• Density: 1.177g/cm³
• LogP: 3.00750

Purity/Quality:

99% ^*data from raw suppliers

N-(3-CHLOROPHENYL)-2-METHYL-PROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-chlorophenyl)-2-methyl-propanamide

There total 4 articles about N-(3-chlorophenyl)-2-methyl-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(3-chlorophenyl)-2-methyl-propan-1-one (55649-98-4) → N-(3-chlorophenyl)isobutyramide (7017-17-6)

Guidance literature:

With hydroxylamine hydrochloride; trifluoroacetic acid; at 70 ℃; for 12h; regioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/acs.orglett.7b02105

Reference yield: 68.0%

Isobutyronitrile (78-82-0) + CF3O3S(1-)*C21H19ClI(1+) → N-(3-chlorophenyl)isobutyramide (7017-17-6)

Guidance literature:

With water; copper diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 20h;

DOI:10.1016/j.tetlet.2021.153048

Reference yield: 68.0%

Isobutyronitrile (78-82-0) + (3-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate (1416277-01-4) → N-(3-chlorophenyl)isobutyramide (7017-17-6)

Guidance literature:

With copper diacetate; In water; 1,2-dichloro-ethane; at 80 ℃; for 20h; Schlenk technique; Sealed tube;

upstream raw materials:

1-(3-chlorophenyl)-2-methyl-propan-1-one

Isobutyronitrile

(3-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate

Refernces

• 1、 -. "Preparation method of N-aryl amide compound". Paragraph 0152-0157. . Retrieved 2020/07/13.