3-Chlorophenylisopropyl ketone

Base Information

• Chemical Name: 3-Chlorophenylisopropyl ketone
• CAS No.: 55649-98-4
• Molecular Formula: C10H11ClO
• Molecular Weight: 182.65
• Hs Code.: 2914700090
• Mol file: 55649-98-4.mol

Synonyms:m-chlorophenyl isopropyl ketone;

Chemical Property of 3-Chlorophenylisopropyl ketone

Chemical Property:

• PSA: 17.07000
• LogP: 3.17870

Purity/Quality:

99% ^*data from raw suppliers

1-(3-Chloro-phenyl)-2-methyl-propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chlorophenylisopropyl ketone

There total 9 articles about 3-Chlorophenylisopropyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 3'-chloro-propiophenone (34841-35-5) → 1-(3-chlorophenyl)-2-methyl-propan-1-one (55649-98-4)

Guidance literature:

With C₃₄H₂₇IrN₂P⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-); caesium carbonate; at 65 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201405990

Reference yield: 86.0%

5-(iso-propyl)-1-aza-5-stannabicyclo[3.3.3]undecane + m-Chlorobenzoyl chloride (618-46-2) → 1-(3-chlorophenyl)-2-methyl-propan-1-one (55649-98-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; In acetonitrile; at 60 ℃; for 12h; Sealed tube;

DOI:10.1002/anie.201609930

Reference yield: 62.0%

2-(3-chlorophenyl)-2-oxoacetic acid (26767-07-7) + isobutyraldehyde (78-84-2) → 1-(3-chlorophenyl)-2-methyl-propan-1-one (55649-98-4)

Guidance literature:

With dipotassium peroxodisulfate; iron(III)-acetylacetonate; di-tert-butyl peroxide; In ethyl acetate; at 120 ℃; for 2h; Sealed tube;

DOI:10.1002/chem.202000114

upstream raw materials:

propane

carbon monoxide

m-chlorophenyltrimethylsilane

m-Chlorobenzaldehyde

Downstream raw materials:

N-(3-chlorophenyl)isobutyramide

2-bromo-1-(3-chlorophenyl)-2-methylpropan-1-one

(S)-1-(3-chlorophenyl)-2-methylpropan-1-ol

(R)-1-(3-chlorophenyl)-2-methylpropan-1-ol

Refernces

• 1、 Zhou, Fangyuan,Li, Lesong,Lin, Kao,Zhang, Feng,Deng, Guo-Jun,Gong, Hang. "Iron-Catalyzed Cleavage Reaction of Keto Acids with Aliphatic Aldehydes for the Synthesis of Ketones and Ketone Esters". supporting information. p. 4246 - 4250. Retrieved 2020/03/11.
• 2、 Sklyaruk, Jan,Borghs, Jannik C.,El-Sepelgy, Osama,Rueping, Magnus. "Catalytic C1 Alkylation with Methanol and Isotope-Labeled Methanol". supporting information. p. 775 - 779. Retrieved 2019/01/04.