methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate

Base Information

Chemical Name:methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate
CAS No.:176208-24-5
Molecular Formula:C₁₈H₁₈N₄O₄
Molecular Weight:354.365
Hs Code.:

Synonyms:methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate

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Chemical Property of methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate

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Technology Process of methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate

There total 4 articles about methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 176208-23-4
methyl 4-<4-<(2-amino-4(3H)-oxopyrimidin-6-yl)hydrazono>-1-hydroxycyclohexyl>benzoate

: 176208-24-5
methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate

Guidance literature:: In diphenylether; for 2.5h; Heating;
DOI:10.3987/com-95-7260

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 176208-24-5
methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / tetrahydrofuran; hexane / 1.) 10 min, -100 deg C; 2.) -95 deg C, 10 min, up to RT

2: 2.5N NaOH / 2-methoxy-ethanol / 100 °C

3: conc. HCl / 4 h / Heating

4: 80 percent / 2-methoxy-ethanol / 15 h / Heating

5: 88 percent / diphenyl ether / 2.5 h / Heating

With hydrogenchloride; sodium hydroxide; n-butyllithium; In tetrahydrofuran; diphenylether; hexane; 2-methoxy-ethanol;
DOI:10.3987/com-95-7260

Reference yield:

: 623-00-7
4-bromobenzenecarbonitrile

: 176208-24-5
methyl 4-(2-amino-6-hydroxy-3,5,6,7,8,9-hexahydro-4-oxo-4H-pyrimido<4,5-b>indol-6-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / tetrahydrofuran; hexane / 1.) 10 min, -100 deg C; 2.) -95 deg C, 10 min, up to RT

2: 2.5N NaOH / 2-methoxy-ethanol / 100 °C

3: conc. HCl / 4 h / Heating

4: 80 percent / 2-methoxy-ethanol / 15 h / Heating

5: 88 percent / diphenyl ether / 2.5 h / Heating

With hydrogenchloride; sodium hydroxide; n-butyllithium; In tetrahydrofuran; diphenylether; hexane; 2-methoxy-ethanol;
DOI:10.3987/com-95-7260