Cefodizima

Base Information

• Chemical Name: Cefodizima
• CAS No.: 69739-16-8
• Molecular Formula: C20H20N6O7S4
• Molecular Weight: 584.679
• European Community (EC) Number: 700-301-3,615-001-7
• DSSTox Substance ID: DTXSID60860905
• Wikipedia: Cefodizime
• NCI Thesaurus Code: C98224
• Mol file: 69739-16-8.mol

Synonyms:cefodizime;cefodizime disodium;cefodizime, dipotassium salt, (6R-(6alpha,7beta(Z)))-isomer;cefodizime, disodium salt, (6R-(6alpha,7beta(Z)))-isomer;HR 221;HR-221;Modivid

Chemical Property of Cefodizima

Chemical Property:

• Refractive Index: 1.851
• PKA: pK1 2.85; pK2 3.37; pK3 4.18(at 25℃)
• PSA: 304.48000
• Density: 1.869 g/cm³
• LogP: 1.90870
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 10
• Exact Mass: 584.02763169
• Heavy Atom Count: 37
• Complexity: 1030

Purity/Quality:

99% ^*data from raw suppliers

Cefodizime ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-42/43
• Safety Statements: 22-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC(=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O)CC(=O)O
• Uses: Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and f or the prophylaxis or treatment of surgical infections. Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.

Technology Process of Cefodizima

There total 3 articles about Cefodizima which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Kenicef (86329-79-5) → 2-<<(2-amino-4-thiazolyl)((Z)-methoxyimino)acetyl>amino>acetoaldehyde (104301-63-5) + 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole (34272-64-5) + (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-(5-carboxymethyl-4-methyl-thiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid (120533-30-4) + cefodizime (69739-16-8,120533-29-1)

Guidance literature:

With sodium hydroxide; at 18 ℃; for 1h; Yield given;

DOI:10.1248/cpb.37.513

Reference yield:

Kenicef (86329-79-5) → 2-<<(2-amino-4-thiazolyl)((Z)-methoxyimino)acetyl>amino>acetoaldehyde (104301-63-5) + 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole (34272-64-5) + (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-3-(5-carboxymethyl-4-methyl-thiazol-2-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid (120533-30-4) + cefodizime (69739-16-8,120533-29-1)

Guidance literature:

With sodium hydroxide; at 18 ℃; for 1h; degradation in variuos conditions;

DOI:10.1248/cpb.37.513

Reference yield:

→ cefodizime (69739-16-8,120533-29-1)

Guidance literature:

upstream raw materials:

Kenicef

Refernces

• 1、 -. "Method for producing cephalosporins". Page 3. . Retrieved 2010/02/05.