5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

Base Information

Chemical Name:5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole
CAS No.:1017279-15-0
Molecular Formula:C₃₅H₄₃N₃O₅
Molecular Weight:585.744
Hs Code.:

Synonyms:5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

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Chemical Property of 5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

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Technology Process of 5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

There total 8 articles about 5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1017279-13-8
5-amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

: 1017279-15-0
5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

Guidance literature:: With dmap; In 1,4-dioxane; for 48h; Reflux;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-11-6
5-[allyl(tert-butoxycarbonyl)amino]-3-(tert-butoxycarbonyl)-1-methyl-1,2-dihydro-3H-benzo[e]indole

: 1017279-15-0
5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 0 - 20 °C

2.1: tetrahydrofuran / 12 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: dmap / 1,4-dioxane / 48 h / Reflux

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-57-0
C₁₆H₁₈N₂

: 1017279-15-0
5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 12 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: dmap / 1,4-dioxane / 48 h / Reflux

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.12.007