tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate
CAS No.:1448190-12-2
Molecular Formula:C₂₁H₂₇N₃O₅S
Molecular Weight:433.528
Hs Code.:

Synonyms:tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

Suppliers and Price of tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

There total 4 articles about tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1448190-11-1
2-(aminomethyl)-5-(4-methyl-1,3-thiazol-5-yl)phenol

: 13726-69-7,946610-68-0
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

: 1448190-12-2
tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 78.0%

: 1448190-11-1
2-(aminomethyl)-5-(4-methyl-1,3-thiazol-5-yl)phenol

: 946610-68-0
trans-N-(tert-butoxycarbonyl)-4-hydroxy-L-proline

: 1448190-12-2
tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

Guidance literature:: trans-N-(tert-butoxycarbonyl)-4-hydroxy-L-proline; With 1-hydroxy-7-aza-benzotriazole; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

2-(aminomethyl)-5-(4-methyl-1,3-thiazol-5-yl)phenol; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; pH=> 9; Time;

Reference yield:

: 288067-35-6
4-bromo-2-hydroxy-benzonitrile

: 1448190-12-2
tert-butyl (2S,4R)-4-hydroxy-2-[[2-hydroxy-4-(4-methylthiazol-5-yl)phenyl]methyl carbamoyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; palladium diacetate / 1-methyl-pyrrolidin-2-one / 3 h / 110 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 50 °C / Cooling with ice

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With lithium aluminium tetrahydride; potassium acetate; palladium diacetate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;