Acridine, 2-amino-6-chloro-

Base Information

• Chemical Name: Acridine, 2-amino-6-chloro-
• CAS No.: 40505-20-2
• Molecular Formula: C13H9ClN2
• Molecular Weight: 228.677
• DSSTox Substance ID: DTXSID90193516
• Nikkaji Number: J55.081G
• Wikidata: Q83066259
• ChEMBL ID: CHEMBL146648
• Mol file: 40505-20-2.mol

Synonyms:ACRIDINE, 2-AMINO-6-CHLORO-;40505-20-2;BRN 0166510;3-Amino-8-chloroacridine (European);6-Chloro-2-acridinamine;2-Acridinamine, 6-chloro-;CHEMBL146648;DTXSID90193516

Chemical Property of Acridine, 2-amino-6-chloro-

Chemical Property:

• Vapor Pressure: 1.68E-08mmHg at 25°C
• Boiling Point: 456°Cat760mmHg
• Flash Point: 229.6°C
• PSA: 38.91000
• Density: 1.384g/cm³
• LogP: 4.20480
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 228.0454260
• Heavy Atom Count: 16
• Complexity: 258

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC2=NC3=C(C=C21)C=C(C=C3)N)Cl

Technology Process of Acridine, 2-amino-6-chloro-

There total 2 articles about Acridine, 2-amino-6-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-aniline (108-42-9) → 3-Amino-8-chloroacridin (40505-20-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; copper; butanol-⁽¹⁾

2: POCl₃ / Erwaermen des Reaktionsprodukts mit Natrium-Amalgam und wss. NaOH

With copper; potassium carbonate; trichlorophosphate; butan-1-ol;

DOI:10.1039/jr9420000377

Reference yield:

2-(3-chlorophenylamino)-5-nitrobenzoic acid (90656-49-8) → 8-chloro-acridin-2-ylamine (23045-21-8) + 3-Amino-8-chloroacridin (40505-20-2)

Guidance literature:

With trichlorophosphate; Erwaermen des Reaktionsprodukts mit Natrium-Amalgam und wss. NaOH;

DOI:10.1039/jr9420000377

upstream raw materials:

2-(3-chlorophenylamino)-5-nitrobenzoic acid

3-chloro-aniline