(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

Base Information

Chemical Name:(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone
CAS No.:516509-11-8
Molecular Formula:C₃₆H₃₈O₄Si
Molecular Weight:562.781
Hs Code.:

Synonyms:(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

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Chemical Property of (+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

Chemical Property:

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Technology Process of (+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

There total 7 articles about (+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 100-07-2
4-methoxy-benzoyl chloride

: 516509-06-1
(+/-)-[3-(benzofuran-2-yl)-1-methylpropoxy](tert-butyl)diphenylsilane

: 516509-11-8
(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

Guidance literature:: tin(IV) chloride; In dichloromethane; at 0 ℃; for 5h;
DOI:10.1002/1522-2675(200209)85:9<2990::AID-HLCA2990>3.0.CO;2-R

Reference yield:

: 126252-14-0
(+/-)-γ-hydroxy-γ-methylbutyric acid methylester

: 516509-11-8
(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / 1H-imidazole; DMAP / CH₂Cl₂ / 18 h / 0 - 20 °C

2: 99 percent / KOH / ethanol; H₂O / 14 h / 20 °C

3: DCC; DMAP / CH₂Cl₂ / 14 h / 20 °C

4: Et₃N / dioxane / Heating

5: 72 percent / SnCl₄ / CH₂Cl₂ / 5 h / 0 °C

With 1H-imidazole; dmap; potassium hydroxide; triethylamine; dicyclohexyl-carbodiimide; tin(IV) chloride; In 1,4-dioxane; ethanol; dichloromethane; water; 4: intramolecular Wittig cyclization / 5: Friedel-Crafts acylation;
DOI:10.1002/1522-2675(200209)85:9<2990::AID-HLCA2990>3.0.CO;2-R

Reference yield:

: 70340-04-4
(2-hydroxybenzyl)triphenylphosphonium bromide

: 516509-11-8
(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: DCC; DMAP / CH₂Cl₂ / 14 h / 20 °C

2: Et₃N / dioxane / Heating

3: 72 percent / SnCl₄ / CH₂Cl₂ / 5 h / 0 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; tin(IV) chloride; In 1,4-dioxane; dichloromethane; 2: intramolecular Wittig cyclization / 3: Friedel-Crafts acylation;
DOI:10.1002/1522-2675(200209)85:9<2990::AID-HLCA2990>3.0.CO;2-R