(+/-)-γ-hydroxy-γ-methylbutyric acid methylester

Base Information

• Chemical Name: (+/-)-γ-hydroxy-γ-methylbutyric acid methylester
• CAS No.: 126252-14-0
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.159
• Mol file: 126252-14-0.mol

Synonyms:(+/-)-γ-hydroxy-γ-methylbutyric acid methylester

Chemical Property of (+/-)-γ-hydroxy-γ-methylbutyric acid methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-γ-hydroxy-γ-methylbutyric acid methylester

There total 6 articles about (+/-)-γ-hydroxy-γ-methylbutyric acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

levulinic acid methyl ester (624-45-3) → (+/-)-γ-hydroxy-γ-methylbutyric acid methylester (126252-14-0) + 5-methyl-dihydro-furan-2-one (108-29-2)

Guidance literature:

With hydrogen; In methanol; at 69.84 ℃; for 0.5h; under 22502.3 Torr; Autoclave;

DOI:10.1016/j.apcata.2013.10.059

Reference yield: 40.0%

levulinic acid methyl ester (624-45-3) → (+/-)-γ-hydroxy-γ-methylbutyric acid methylester (126252-14-0) + γ-valerolactone (108-29-2)

Guidance literature:

With ruthenium-carbon composite; hydrogen; at 79.84 ℃; for 4h; under 37503.8 Torr; Autoclave;

DOI:10.1016/j.molcata.2013.11.031

Reference yield:

levulinic acid methyl ester (624-45-3) → (+/-)-γ-hydroxy-γ-methylbutyric acid methylester (126252-14-0) + (R)-5-methyl-2-oxotetrahydrofuran (58917-25-2) + (S)-γ-valerolactone (19041-15-7)

Guidance literature:

With L-Tartaric acid; hydrogen; acetic acid; sodium bromide; In tetrahydrofuran; water; at 99.84 ℃; for 20h; under 67506.8 Torr; Reagent/catalyst; enantioselective reaction; Autoclave;

DOI:10.1007/s10562-017-1968-x

upstream raw materials:

levulinic acid methyl ester

(2-furyl)methyl alcohol

methanol

Downstream raw materials:

(+/-)-4-{[(tert-butyl)diphenylsilyl]oxy}pentanoic acid

(+/-)-[3-(benzofuran-2-yl)-1-methylpropoxy](tert-butyl)diphenylsilane

(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-methoxyphenyl)methanone

(+/-)-[2-(3-{[(tert-butyl)diphenylsilyl]oxy}butyl)benzofuran-3-yl](4-hydroxyphenyl)methanone

Refernces

• 1、 Hengne,Biradar,Rode. "Surface species of supported ruthenium catalysts in selective hydrogenation of levulinic esters for bio-refinery application". . p. 779 - 787. Retrieved 2012.
• 2、 Meier, Sebastian,Riisager, Anders,Yang, Song,Zhao, Wenfeng. "Ammonia borane enabled upgrading of biomass derivatives at room temperature". supporting information. p. 5972 - 5977. Retrieved 2020/11/03.
• 3、 Osawa, Tsutomu,Tanabe, Yuya,Fujiwara, Manabu. "Sodium Ion as the Most Essential and Effective Element for the Enantio-Differentiating Hydrogenation of Prochiral Ketones over Tartaric Acid Modified Ni Catalyst". . p. 686 - 692. Retrieved 2017/03/08.