(2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate
CAS No.:1610036-19-5
Molecular Formula:C₁₆H₂₁NO₅
Molecular Weight:307.346
Hs Code.:

Synonyms:(2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate

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Chemical Property of (2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate

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Technology Process of (2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate

There total 3 articles about (2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1610036-18-4
(2R,3S,4R)-1-benzyl 2-methyl 4-hydroxy-3-methylpyrrolidine-1,2-dicarboxylate

: 74-88-4
methyl iodide

: 1610036-19-5
(2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: (2R,3S,4R)-1-benzyl 2-methyl 4-hydroxy-3-methylpyrrolidine-1,2-dicarboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 1367552-64-4
(2R,3S,4R)-1-benzyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)-3-methylpyrrolidine-1,2-dicarboxylate

: 1610036-19-5
(2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1367552-62-2
1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate

: 1610036-19-5
(2R,3S,4R)-1-benzyl 2-methyl 4-methoxy-3-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 1 h

1.2: 0.75 h / -45 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 20 °C

With copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; mineral oil;