methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

Base Information

Chemical Name:methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate
CAS No.:1018674-51-5
Molecular Formula:C₂₅H₃₅NO₄
Molecular Weight:413.557
Hs Code.:

Synonyms:methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

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Chemical Property of methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

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Technology Process of methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

There total 5 articles about methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 956928-36-2
cyclopentyl (2S)-amino(cyclohexyl)acetate hydrochloride

: 71348-24-8,71348-27-1
methyl (2E)-3-(4-acetylphenyl)acrylate

: 1018674-51-5
methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

Guidance literature:: cyclopentyl (2S)-amino(cyclohexyl)acetate hydrochloride; methyl (2E)-3-(4-acetylphenyl)acrylate; With acetic acid; triethylamine; In tetrahydrofuran; at 50 ℃; for 18h; Molecular sieve;

With sodium tetrahydroborate; In tetrahydrofuran; methanol;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1018674-51-5
methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 2 h / 130 °C

2: acetic acid; triethylamine / tetrahydrofuran / 18 h / 50 °C / Molecular sieve

With tetrabutylammomium bromide; sodium hydrogencarbonate; acetic acid; triethylamine; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 914604-31-2
(S)-tert-butoxycarbonylamino-cyclohexyl-acetic acid cyclopentyl ester

: 1018674-51-5
methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 24 h / 20 °C

2: acetic acid; triethylamine / tetrahydrofuran / 18 h / 50 °C / Molecular sieve

With hydrogenchloride; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;