methyl (2E)-3-(4-acetylphenyl)acrylate

Base Information

• Chemical Name: methyl (2E)-3-(4-acetylphenyl)acrylate
• CAS No.: 71348-24-8
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.225
• Mol file: 71348-24-8.mol

Synonyms:

Chemical Property of methyl (2E)-3-(4-acetylphenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2E)-3-(4-acetylphenyl)acrylate

There total 23 articles about methyl (2E)-3-(4-acetylphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Iodoacetophenone (13329-40-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl (2E)-3-(4-acetylphenyl)acrylate (71348-24-8,71348-27-1)

Guidance literature:

With PdCl₂[4,4'-bis(n-C₁₀F₂₁CH₂OCH₂)-2,2'-bipyridine]; triethylamine; In N,N-dimethyl-formamide; at 145 ℃; for 0.167h; Reagent/catalyst; Catalytic behavior; Microwave irradiation;

DOI:10.1002/jccs.201400252

Reference yield: 99.0%

para-bromoacetophenone (99-90-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl (2E)-3-(4-acetylphenyl)acrylate (71348-24-8,71348-27-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1055/s-2008-1072579

Reference yield: 99.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + 4-(N-acetylamino)acetophenone (2719-21-3,150667-24-6) → methyl (2E)-3-(4-acetylphenyl)acrylate (71348-24-8,71348-27-1)

Guidance literature:

4-(N-acetylamino)acetophenone; With boron trifluoride methanol complex; In methanol; at 65 ℃; Inert atmosphere;

With tert.-butylnitrite; In methanol; at 0 ℃; for 1h; Inert atmosphere;

acrylic acid methyl ester; With palladium diacetate; In methanol; at 20 ℃; for 12.25h; Inert atmosphere;

DOI:10.1002/adsc.201200929

upstream raw materials:

p-formylacetophenone

methyl chloroacetate

para-bromoacetophenone

acrylic acid methyl ester

Downstream raw materials:

methyl (2E)-3-[4-(1-{[(1S)-1-cyclohexyl-2-(cyclopentyloxy)-2-oxoethyl]amino}ethyl)phenyl]acrylate

(E)-N-(3-hydroxypropyl)-4-acetylcinnamamide

C₁₄H₁₇NO₃

(E)-N-(1-hydroxy-2-methylpropan-2-yl)-4-acetylcinnamamide