4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

Base Information

Chemical Name:4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide
CAS No.:1607005-22-0
Molecular Formula:C₂₇H₂₈FN₅O₂
Molecular Weight:473.55
Hs Code.:

Synonyms:4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

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Chemical Property of 4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

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Technology Process of 4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

There total 9 articles about 4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1607005-20-8
4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

: 124-40-3
dimethyl amine

: 1607005-22-0
4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1607005-19-5
4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid tert-butyl ester

: 1607005-22-0
4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5305-40-8
2,6-dichloro-pyrimidine carbaldehyde

: 1607005-22-0
4-{4-[(4-tert-butylbenzoylamino)methyl]-3-fluorophenyl}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 48 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 150 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;