(7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol

Base Information

Chemical Name:(7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol
CAS No.:1432519-37-3
Molecular Formula:C₂₅H₂₅FO₆S₂
Molecular Weight:504.6
Hs Code.:

Synonyms:(7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol

Chemical Property:

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Technology Process of (7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol

There total 11 articles about (7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1432519-36-2
(3S,6R,7R)-8,8-bis(benzenesulfonyl)-13-fluoro-6-{[(1R,2S,5R)-5methyl-2-(propan-2-yl)cyclohexyl]oxy}-5-oxatricyclo[8.4.0.03,7]tetradeca-1⁽¹⁴⁾,10,12-trien-4-one

: 1432519-37-3
(7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at 0 ℃; for 9h;
DOI:10.1039/c3ob40115d

Reference yield:

: C₂₃H₂₃FO₂S₂

: 1432519-37-3
(7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

2: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

3: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 7 h / 0 °C / Cooling with ice

5: caesium carbonate / tetrahydrofuran / 1.33 h / 0 - 20 °C / Cooling with ice

6: 10 wt% Pd(OH)2 on carbon; acetic acid / ethyl acetate / 36 h / 20 °C / 2585.81 Torr

7: diisobutylaluminium hydride / toluene / 9 h / 0 °C

With pyridine; hydrogenchloride; dmap; n-butyllithium; diphenyl diselenide; 10 wt% Pd(OH)2 on carbon; diisobutylaluminium hydride; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1039/c3ob40115d

Reference yield:

: 77532-79-7
3-fluoro-6-methylbenzonitrile

: 1432519-37-3
(7R,8S)-6,6-bis{(benzenesulfonyl)-2-fluoro-8-(hydroxymethyl)6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl}methanol

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane

2.1: diisobutylaluminium hydride; hydrogen bromide / dichloromethane / Cooling with ice

3.1: toluene-4-sulfonic acid / methanol / 1 h / 50 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 - 0 °C / Cooling with ice

4.2: 0.67 h / -78 - 0 °C / Cooling with ice

5.1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

6.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

7.1: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 7 h / 0 °C / Cooling with ice

9.1: caesium carbonate / tetrahydrofuran / 1.33 h / 0 - 20 °C / Cooling with ice

10.1: 10 wt% Pd(OH)2 on carbon; acetic acid / ethyl acetate / 36 h / 20 °C / 2585.81 Torr

11.1: diisobutylaluminium hydride / toluene / 9 h / 0 °C

With pyridine; hydrogenchloride; dmap; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); diphenyl diselenide; 10 wt% Pd(OH)2 on carbon; hydrogen bromide; diisobutylaluminium hydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1039/c3ob40115d