4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide
CAS No.:1353895-80-3
Molecular Formula:C₂₅H₂₁F₂NO₄
Molecular Weight:437.443
Hs Code.:

Synonyms:4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

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Chemical Property of 4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

Chemical Property:

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Technology Process of 4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

There total 7 articles about 4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 371-41-5
4-Fluorophenol

: 1353895-77-8
4-fluoro-2-(4-bromophenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

: 1353895-80-3
4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In toluene; at 50 ℃; for 16h; Sealed tube; Inert atmosphere;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1353895-80-3
4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / toluene; mineral oil / 20 °C

2: zinc(II) chloride / ethanol / 120 °C

3: Selectfluor / acetonitrile / 24 h / 20 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 60 °C

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C / Inert atmosphere

6: caesium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 50 °C / Sealed tube

7: potassium phosphate / palladium diacetate; XPhos / toluene / 16 h / 50 °C / Sealed tube; Inert atmosphere

With potassium phosphate; water; sodium hydride; benzotriazol-1-ol; caesium carbonate; Selectfluor; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc(II) chloride; palladium diacetate; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; toluene; acetonitrile; mineral oil;

Reference yield:

: 1353895-76-7
4-fluoro-2-(4-bromophenyl)-5-hydroxy-N-methylbenzofuran-3-carboxamide

: 1353895-80-3
4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 50 °C / Sealed tube

2: potassium phosphate / palladium diacetate; XPhos / toluene / 16 h / 50 °C / Sealed tube; Inert atmosphere

With potassium phosphate; caesium carbonate; palladium diacetate; XPhos; In 1-methyl-pyrrolidin-2-one; toluene;