5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

Base Information

Chemical Name:5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid
CAS No.:1353895-89-2
Molecular Formula:C₃₁H₂₃F₂NO₆
Molecular Weight:543.524
Hs Code.:

Synonyms:5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

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Chemical Property of 5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

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Technology Process of 5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

There total 11 articles about 5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.4%

: 1353895-87-0
methyl 5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoate

: 1353895-89-2
5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

Guidance literature:: methyl 5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoate; With methanol; sodium hydroxide; In tetrahydrofuran; at 20 - 60 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

: 26510-95-2
ethyl 4-Bromobenzoylacetate

: 1353895-89-2
5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: zinc(II) chloride / ethanol / 120 °C

2: Selectfluor / acetonitrile / 24 h / 20 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 60 °C

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C / Inert atmosphere

5: caesium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 50 °C / Sealed tube

6: potassium phosphate / palladium diacetate; XPhos / toluene / 16 h / 50 °C / Sealed tube; Inert atmosphere

7: boron trichloride / dichloromethane / 3 h / 20 °C

8: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

9: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 100 °C / Inert atmosphere

10: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 20 - 60 °C

With methanol; potassium phosphate; water; boron trichloride; sodium carbonate; benzotriazol-1-ol; caesium carbonate; Selectfluor; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1353895-89-2
5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: sodium hydride / toluene; mineral oil / 20 °C

2: zinc(II) chloride / ethanol / 120 °C

3: Selectfluor / acetonitrile / 24 h / 20 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 60 °C

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C / Inert atmosphere

6: caesium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 50 °C / Sealed tube

7: potassium phosphate / palladium diacetate; XPhos / toluene / 16 h / 50 °C / Sealed tube; Inert atmosphere

8: boron trichloride / dichloromethane / 3 h / 20 °C

9: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

10: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 100 °C / Inert atmosphere

11: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 20 - 60 °C

With methanol; potassium phosphate; water; boron trichloride; sodium hydride; sodium carbonate; benzotriazol-1-ol; caesium carbonate; Selectfluor; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; mineral oil;