2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester
CAS No.:852065-01-1
Molecular Formula:C₂₈H₅₄O₆Si₂
Molecular Weight:542.904
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester

There total 4 articles about 2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 852064-99-4
(1R,2R)-3,6-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-4-ene-1,2-diol

: 3282-30-2
pivaloyl chloride

: 852065-01-1
2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester

Guidance literature:: With pyridine; dmap; at 40 ℃; for 27h;
DOI:10.1021/ol050105c

Reference yield:

: 852064-74-5
1-[(4S,5S)-5-(1-Hydroxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-prop-2-en-1-ol

: 852065-01-1
2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Grubbs second-generation catalyst / CH₂Cl₂ / 2 h / Heating

2: 537 mg / 2,6-lutidine / CH₂Cl₂ / 3 h / 0 °C

3: 344 mg / SnCl₂ / CH₂Cl₂ / 72 h / 20 °C

4: 96 percent / DMAP; pyridine / 27 h / 40 °C

With pyridine; 2,6-dimethylpyridine; dmap; tin(ll) chloride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; 1: ring-closing metathesis;
DOI:10.1021/ol050105c

Reference yield:

: 852064-98-3
(3aR,7aR)-4,7-Bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxole

: 852065-01-1
2,2-Dimethyl-propionic acid (1R,6R)-2,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-(2,2-dimethyl-propionyloxy)-cyclohex-3-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 344 mg / SnCl₂ / CH₂Cl₂ / 72 h / 20 °C

2: 96 percent / DMAP; pyridine / 27 h / 40 °C

With pyridine; dmap; tin(ll) chloride; In dichloromethane;
DOI:10.1021/ol050105c