9-Methoxycamptothecin

Base Information

Chemical Name:9-Methoxycamptothecin
CAS No.:39026-92-1
Molecular Formula:C21H18N2O5
Molecular Weight:378.384
Hs Code.:
NSC Number:176323
DSSTox Substance ID:DTXSID00192292
Nikkaji Number:J258.663K
Wikidata:Q72489419
Metabolomics Workbench ID:142056
ChEMBL ID:CHEMBL522112
Mol file:39026-92-1.mol

Synonyms:9-methoxycamptothecin

Suppliers and Price of 9-Methoxycamptothecin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
9-Methoxycamptothecin >98%
20 mg
$ 280.00

ChemScene
9-Methoxycamptothecin
10mg
$ 100.00

ChemScene
9-Methoxycamptothecin
5mg
$ 60.00

ChemScene
9-Methoxycamptothecin
20mg
$ 180.00

AvaChem
9-Methoxycamptothecin
1mg
$ 490.00

Arctom
9-Methoxycamptothecine ≥98%
20mg
$ 138.00

Total 56 raw suppliers

Chemical Property of 9-Methoxycamptothecin

Chemical Property:

Melting Point:223-225℃
Boiling Point:773.1 °C at 760 mmHg
PKA:11.20±0.20(Predicted)
Flash Point:421.4 °C
PSA：90.65000
Density:1.5 g/cm³
LogP:2.08820
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:378.12157168
Heavy Atom Count:28
Complexity:790

Purity/Quality:

99%, ^*data from raw suppliers

9-Methoxycamptothecin >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5OC)N=C4C3=C2)O
Isomeric SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5OC)N=C4C3=C2)O

Technology Process of 9-Methoxycamptothecin

There total 6 articles about 9-Methoxycamptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 67656-30-8,130194-92-2
10-hydroxycamptothecin

: 39026-92-1
9-methoxycamptothecin

Guidance literature:: In 1,4-dioxane; methanol; diethyl ether; for 1h; Ambient temperature;
DOI:10.1248/cpb.39.3183

Reference yield:

20-O-acetyl-10-methoxycamptothecin: 20-O-acetyl-10-methoxycamptothecin

: 86639-48-7
Camptothecin 1-oxide

: 7688-64-4
(20S)-20-O-Acetylcamptothecin

: 57-15-8
1,1,1-trichloro-2-methyl-2-propanol

: 39026-92-1
9-methoxycamptothecin

Guidance literature:: With pyridine; sulfuric acid; acetic anhydride; In 1,4-dioxane; methanol;

Reference yield:

: 91421-42-0
rubitecan

: 39026-92-1
9-methoxycamptothecin

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / SnCl₂; Sn; aq. HCl

2: 36 percent / aq. NaNO₂; H₂SO₄ / Heating

With hydrogenchloride; tin; sulfuric acid; tin(ll) chloride; sodium nitrite;
DOI:10.1016/j.bmcl.2005.05.108