7688-64-4

Basic information

• Product Name: O-acetylcamptothecin
• Synonyms: O-acetylcamptothecin
• CAS NO: 7688-64-4
• Molecular Formula: C₂₂H₁₈N₂O₅
• Molecular Weight: 390.38872
• Mol File: 7688-64-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 271-274 °C
• Boiling Point: 741.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• PKA: 4.69±0.40(Predicted)
• CAS DataBase Reference: O-acetylcamptothecin(CAS DataBase Reference)
• NIST Chemistry Reference: O-acetylcamptothecin(7688-64-4)
• EPA Substance Registry System: O-acetylcamptothecin(7688-64-4)

Safety Data

• Hazardous Substances Data: 7688-64-4(Hazardous Substances Data)

Upstream product

• 7689-03-4 camptothecin 
• 108-24-7 acetic anhydride 
• 71-55-6 1,1,1-trichloroethane 
• 64-19-7 acetic acid 

Downstream Products

• 39026-92-1 9-methoxycamptothecin 
• 31456-25-4 camptothecin 

Relevant articles and documents

An alternative preparation of camptothecin 20(S)-acetate

Camptothecin 20(S) acetate was obtained in 60% yield by reaction of camptothecin with trichloroethane in sulfuric acid. This method represents another alternative preparation of camptothecin ester using trichloroethane as acylating agent.

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Methods Of Making Esters Of Camptothecins

Methods of preparing CPT-esters are described. The methods include using at least one acid in the esterification reactions or acylation reactions of camptothecins.

Studies on phytochemicals : Part XV -Investigation on the alkaloidal constituents of Indian Mappia foetida

Three antitumour alkaloids, camptothecin (1), 9-methoxycamptothecin (2) and 20-O-acetylcamptothecin (3) have been isolated from the stems of Indian Mappia foetida. The presence of 3 in this indigenous species is reported for the first time. The 13C NMR spectra of the alkaloids 2 and 3 have been studied. The effects of different solvent systems and the variation of temperature on the 1H NMR spectra of these compounds (1-3) have been discussed.