(R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide

Base Information

Chemical Name:(R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide
CAS No.:553614-26-9
Molecular Formula:C₂₀H₂₅ClN₂O₄S
Molecular Weight:424.948
Hs Code.:

Synonyms:(R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide

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Technology Process of (R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide

There total 2 articles about (R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 553619-61-7
(R)-2-(4-chlorobenzensulfonylamino)-4-methylpentanoic acid amide

: 824-94-2
p-methoxybenzyl chloride

: 553614-26-9
(R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.09.057

Reference yield:

: 80970-09-8
(R)-2-amino-4-methylpentanamide hydrochloride

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 553614-26-9
(R)-2-[(4-chlorobenzensulfonyl)-(4-methoxybenzyl)amino]-4-methylpentanoic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.09.057