tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate

Base Information

Chemical Name:tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate
CAS No.:1450620-54-8
Molecular Formula:C₂₀H₃₆N₂O₅
Molecular Weight:384.516
Hs Code.:

Synonyms:tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate

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Chemical Property of tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate

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Technology Process of tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate

There total 1 articles about tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 278788-66-2
(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate

: 1450620-54-8
tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole; thionyl chloride / dichloromethane / 18 h / -78 - 20 °C

2.1: sodium periodate; ruthenium(III) trichloride hydrate / acetonitrile; ethyl acetate / 12 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 0.25 h / 20 °C

With 1H-imidazole; sodium periodate; n-butyllithium; thionyl chloride; ruthenium(III) trichloride hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1450620-54-8
tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1450620-55-9
tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate

Guidance literature:: With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos; In 1,4-dioxane; at 80 ℃; for 1h;

Reference yield:

: 1450620-54-8
tert-butyl (3S)-3-((4-(tert-butoxycarbonyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinecarboxylate

: 1450620-56-0
tert-butyl (3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 1 h / 80 °C

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 18 h

With lithium aluminium tetrahydride; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; diethyl ether;