8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester
• CAS No.: 149873-68-7
• Molecular Formula: C₂₄H₂₃ClFN₃O₂
• Molecular Weight: 439.917

Synonyms:8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester

Chemical Property of 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester

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Technology Process of 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester

There total 1 articles about 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester (77132-89-9) + pivalaldehyde (630-19-3) → 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester (149873-68-7)

Guidance literature:

nickel; In tetrahydrofuran; ethanol; for 5h; under 760 Torr;

DOI:10.1021/jo00064a014

Reference yield: 97.0%

8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester (149873-68-7) → 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid (149873-69-8)

Guidance literature:

With potassium hydroxide; In methanol; water; for 6h; Heating;

DOI:10.1021/jo00064a014

Reference yield: 71.0%

8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester (149873-68-7) → -(+)-8-chloro-6-(2-fluorophenyl)-1-(1,1-dimethylethyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide (149873-71-2,149951-24-6,149951-41-7)

Guidance literature:

With ammonia; ammonium chloride; at 125 - 130 ℃; for 18h;

DOI:10.1021/jo00064a014

upstream raw materials:

7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester

pivalaldehyde

Downstream raw materials:

8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid

-(+)-8-chloro-6-(2-fluorophenyl)-1-(1,1-dimethylethyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

-8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine

8-chloro-6-(2-fluorophenyl)-5,6-dihydro-1-(1,1-dimethylethyl)-4H-imidazo<1,5-a><1,4>benzodiazepine

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