7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester

Base Information

• Chemical Name: 7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester
• CAS No.: 77132-89-9
• Molecular Formula: C₁₉H₁₅ClFN₃O₃
• Molecular Weight: 387.798

Synonyms:7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester

Chemical Property of 7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester

There total 3 articles about 7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylideneacetic acid ethyl ester (77132-84-4) → 7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester (77132-89-9)

Guidance literature:

With acetic acid; sodium nitrite; for 0.25h; Ambient temperature;

DOI:10.1002/jhet.5570230509

Reference yield:

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylideneacetic acid ethyl ester 4-oxide (77132-80-0) → 7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester (77132-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₃ / CH₂Cl₂ / 3 h / Ambient temperature

2: 85 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

With acetic acid; sodium nitrite; phosphorus trichloride; In dichloromethane;

DOI:10.1002/jhet.5570230509

Reference yield:

6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide (60656-74-8) → 7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester (77132-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) lithium diisopropylamide / 1) hexane, tetrahydrofuran, -50 to -45 deg C 2) warming to room temperature, 2 h

2: PCl₃ / CH₂Cl₂ / 3 h / Ambient temperature

3: 85 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

With acetic acid; lithium diisopropyl amide; sodium nitrite; phosphorus trichloride; In dichloromethane;

DOI:10.1002/jhet.5570230509

upstream raw materials:

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylideneacetic acid ethyl ester

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylideneacetic acid ethyl ester 4-oxide

6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

Downstream raw materials:

Ro 21-6476

8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester

8-chloro-1-(1,1-dimethylethyl)-5,6-dihydro-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

-(+)-8-chloro-6-(2-fluorophenyl)-1-(1,1-dimethylethyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

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