(Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Base Information

• Chemical Name: (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid
• CAS No.: 1354964-44-5
• Molecular Formula: C₂₀H₁₄Cl₂N₄O₄S
• Molecular Weight: 477.328
• Mol file: 1354964-44-5.mol

Synonyms:(Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Chemical Property of (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid

There total 3 articles about (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

o-nitrophenylpyruvic acid (5461-32-5) + 1-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)hydrazine (1354966-31-6) → (E)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid (1354964-43-4) + (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid (1354964-44-5)

Guidance literature:

With acetic acid; In ethanol; at 90 - 100 ℃;

Reference yield:

4-(3,4-dichlorophenyl)butanoic acid (25157-66-8) → (E)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid (1354964-43-4) + (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid (1354964-44-5)

Guidance literature:

Multi-step reaction with 4 steps

1: polyphosphoric acid / 10 h / 130 °C

2: bromine / diethyl ether / 0.5 h / 20 °C

3: 1,4-dioxane / 49 h / 20 - 80 °C

4: acetic acid / ethanol / 1 h / 90 - 100 °C

With bromine; acetic acid; In 1,4-dioxane; diethyl ether; ethanol;

DOI:10.1021/jm401733v

Reference yield:

6,7-dichloro-1,2,3,4-tetrahydro-naphthalen-1-one (25095-57-2) → (E)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid (1354964-43-4) + (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid (1354964-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / diethyl ether / 0.5 h / 20 °C

2: 1,4-dioxane / 49 h / 20 - 80 °C

3: acetic acid / ethanol / 1 h / 90 - 100 °C

With bromine; acetic acid; In 1,4-dioxane; diethyl ether; ethanol;

DOI:10.1021/jm401733v

upstream raw materials:

4-(3,4-dichlorophenyl)butanoic acid

6,7-dichloro-1,2,3,4-tetrahydro-naphthalen-1-one

o-nitrophenylpyruvic acid

1-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)hydrazine