25095-57-2

Usage

Uses

Used in Pharmaceutical Industry:
6,7-Dichloro-1-tetralone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to participate in a range of chemical reactions, contributing to the development of new drugs and medicinal compounds.
Used in Organic Synthesis:
In the field of organic synthesis, 6,7-dichloro-1-tetralone serves as a versatile building block, facilitating the creation of novel chemical compounds for research and development purposes, thereby expanding the scope of chemical knowledge and innovation.
Used in Research and Development:
6,7-Dichloro-1-tetralone is utilized as a research compound to explore its chemical properties and potential applications in creating new materials and compounds, furthering scientific understanding and technological advancement in various chemical and related industries.

InChI:InChI=1/C10H8Cl2O/c11-8-4-6-2-1-3-10(13)7(6)5-9(8)12/h4-5H,1-3H2

Upstream product

• 95-50-1 1,2-dichloro-benzene 
• 50597-19-8 3-(3,4-dichlorobenzoyl)-propionic acid 
• 136294-92-3 Tributyl-(3,4-dichloro-phenyl)-stannane 
• 25157-66-8 4-(3,4-dichlorophenyl)butanoic acid 

Downstream Products

• 1354964-43-4 (E)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid 
• 1354964-44-5 (Z)-2-(2-(7,8-dichloro-4,5-dihydronaphtho[1,2-d]-thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid 
• 153788-15-9 6,7-dichloro-3,4-dihydronaphthalen-1(2H)-one O-p-toluensulfonyl oxime 
• 25095-59-4 6,7-Dichloronaphthyl-1-acethydrazide 

Relevant academic research and scientific papers

Visible-light-induced oxidation/[3 + 2] cycloaddition/oxidative aromatization to construct benzo[ a]carbazoles from 1,2,3,4-tetrahydronaphthalene and arylhydrazine hydrochlorides

An efficient synthesis of benzo[a]carbazoles via visible-light-induced tandem oxidation/[3 + 2] cycloaddition/oxidative aromatization reactions was reported. The benzylic C(sp3)-H of tetrahydronaphthalene was activated through visible-light photoredox catalyst with oxygen as the clean oxidant under mild reaction conditions. This protocol proceeds efficiently with broad substrate scope, and the mechanism study was performed.

NAPTHOQUINONES, PRO-DRUGS, AND METHODS OF USE THEREOF

Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction

The 4EGI-1 is the prototypic inhibitor of eIF4E/eIF4G interaction, a potent inhibitor of translation initiation in vitro and in vivo and an efficacious anticancer agent in animal models of human cancers. We report on the design, synthesis, and in vitro ch

COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION

Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.

Synthesis of 1-tetralone derivatives using a Stille cross coupling/friedel crafts acylation sequence

An efficient method of synthesis of 1-tetralones has been achieved featuring a Stille cross-coupling reaction as the key step.

Synthesis of 1-tetralones by intramolecular Friedel-Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts

Intramolecular Friedel-Crafts reaction of 4-arylbutyric acids efficiently proceeded in the presence of catalytic amounts of Lewis acids such as Bi(NTf2)3 and M(OTf)3 (M=Bi, Ga, In and rare-earth metals) to form 1-tetralones. Chroman-4-one and thiochroman-4-one were also obtained in good yields from 3-phenoxypropionic acid and 3-phenylthiopropionic acid, respectively.

Synthesis of 6/7-halotetralones

The title compounds were prepared from halobromobenzenes via a palladium catalysed coupling followed by cyclisation.