benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Base Information

Chemical Name:benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate
CAS No.:937056-03-6
Molecular Formula:C₂₉H₂₄ClNO₅
Molecular Weight:501.966
Hs Code.:

Synonyms:benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

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Chemical Property of benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

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Technology Process of benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

There total 10 articles about benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 937058-15-6
benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

: 937056-03-6
benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937058-12-3
(2-amino-5-chlorophenyl)(2,3-dihydro-1,4-benzodioxin-5-yl)methanone

: 937056-03-6
benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 1 h / Reflux

2.1: trichlorophosphate / 20 °C / Cooling with ice

2.2: 3 h / 50 °C

3.1: toluene / Heating

4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

With sodium tetrahydroborate; acetic acid; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; toluene; 2.1: Vilsmeier reaction / 2.2: Vilsmeier reaction / 5.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937058-10-1
tert-butyl 4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl carbamate

: 937056-03-6
benzyl 2-[8-chloro-6-(2,3-dihydro-1,4-benzodioxin-5-yl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: manganese(IV) oxide / dichloromethane / 50 °C

2.1: trifluoroacetic acid

3.1: acetic acid / 1 h / Reflux

4.1: trichlorophosphate / 20 °C / Cooling with ice

4.2: 3 h / 50 °C

5.1: toluene / Heating

6.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; acetic acid; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; toluene; 4.1: Vilsmeier reaction / 4.2: Vilsmeier reaction / 7.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054