benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

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Chemical Name:benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate
CAS No.:937058-15-6
Molecular Formula:C₂₉H₂₄ClNO₅
Molecular Weight:501.966
Hs Code.:

Synonyms:benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

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Chemical Property of benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

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Technology Process of benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

There total 9 articles about benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 937058-14-5
benzyl (E)-3-{1-[4-chloro-2-(2,3-dihydro-1,4-benzodioxin-5-ylcarbonyl)phenyl]-1H-pyrrol-2-yl}-2-propenoate

: 937058-15-6
benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937058-12-3
(2-amino-5-chlorophenyl)(2,3-dihydro-1,4-benzodioxin-5-yl)methanone

: 937058-15-6
benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1 h / Reflux

2.1: trichlorophosphate / 20 °C / Cooling with ice

2.2: 3 h / 50 °C

3.1: toluene / Heating

4.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

With sodium tetrahydroborate; acetic acid; trichlorophosphate; In methanol; toluene; 2.1: Vilsmeier reaction / 2.2: Vilsmeier reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937058-10-1
tert-butyl 4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl carbamate

: 937058-15-6
benzyl (E)-3-(1-{4-chloro-2-[2,3-dihydro-1,4-benzodioxin-5-yl(hydroxy)methyl]phenyl}-1H-pyrrol-2-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: manganese(IV) oxide / dichloromethane / 50 °C

2.1: trifluoroacetic acid

3.1: acetic acid / 1 h / Reflux

4.1: trichlorophosphate / 20 °C / Cooling with ice

4.2: 3 h / 50 °C

5.1: toluene / Heating

6.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; acetic acid; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; toluene; 4.1: Vilsmeier reaction / 4.2: Vilsmeier reaction;
DOI:10.1016/j.bmc.2012.02.054