(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid

Base Information

Chemical Name:(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid
CAS No.:1427309-29-2
Molecular Formula:C₁₉H₂₅Cl₂NO₄
Molecular Weight:402.318
Hs Code.:

Synonyms:(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid

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Chemical Property of (3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid

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Technology Process of (3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid

There total 12 articles about (3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid

: 83-38-5
2,6-dichlorobenzaldehyde

: 1427309-29-2
(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In methanol; at 20 - 40 ℃; for 12.5h; Concentration;

Reference yield:

: 1-benzyl (4-methoxyphenyl)methyl (3S,4R)-1-benzyl-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-1,3-dicarboxylate

: 1427309-29-2
(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 38.08 h / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / methanol / 12.5 h / 20 - 40 °C

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In methanol; ethanol;

Reference yield:

: (-)-dibenzoyl-L-tartrate (4-methoxyphenyl)methyl (3SR,4SR)-1-benzyl-4-methylpyrrolidine-3-carboxylate

: 1427309-29-2
(3S,4R)-3-[2-(tert-butoxy)-2-oxoethyl]-1-[(2,6-dichlorophenyl)methyl]-4-methylpyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; ethyl acetate

2.1: lithium diisopropyl amide; 20% palladium hydroxide-activated charcoal / tetrahydrofuran; hexane / 0.5 h / Cooling with ethanol-dry ice

2.2: 0.65 h

3.1: sodium tris(acetoxy)borohydride; acetic acid / methanol / 12.5 h / 20 - 40 °C

With 20% palladium hydroxide-activated charcoal; sodium tris(acetoxy)borohydride; acetic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; water; ethyl acetate;