tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate
CAS No.:1416000-69-5
Molecular Formula:C₃₃H₃₁F₃N₆O₄
Molecular Weight:632.642
Hs Code.:

Synonyms:tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

There total 9 articles about tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.8%

: 14221-01-3
tetrakis(triphenylphosphine) palladium⁽⁰⁾

: 1416000-69-5
tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

Guidance literature:: With sodium carbonate; In dichloromethane;

Reference yield: 43.8%

: 1416000-67-3
tert-butyl 4-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

: 163105-89-3,600726-67-8
2-methoxy-pyridine-5-boronic acid

: 1416000-69-5
tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 4h; Inert atmosphere; Reflux;

Reference yield:

: 127094-57-9
4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

: 1416000-69-5
tert-butyl 4-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tert-butyl alcohol; dichloromethane / 24 h / 20 °C

2: sodium tetrahydroborate; ethanol / 18 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 3 h / 20 °C

4: N,N-dimethyl acetamide / 0.67 h / 160 °C / Microwave irradiation

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 4 h / Inert atmosphere; Reflux

With manganese(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; sodium carbonate; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl acetamide; toluene; tert-butyl alcohol;