(S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride

Base Information

Chemical Name:(S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride
CAS No.:98482-72-5
Molecular Formula:C₁₇H₂₇N₃O₃*ClH
Molecular Weight:357.881
Hs Code.:

Synonyms:(S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride

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Chemical Property of (S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride

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Technology Process of (S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride

There total 5 articles about (S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98482-71-4
(benzyloxycarbonyl)-β-tert-butyl-L-aspartyl-ψ(CH2-NH)-L-phenylalanine amide

: 98482-72-5
(S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 4h;
DOI:10.1021/jm00150a020

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 98482-72-5
(S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / sodium cyanoborohydride / methanol; acetic acid / 3 h

2: H₂, HCl / 10 percent Pd/C / ethanol / 4 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In methanol; ethanol; acetic acid;
DOI:10.1021/jm00150a020

Reference yield:

: 5545-52-8
Z-D(tBu)-OH

: 98482-72-5
(S)-3-Amino-4-((S)-1-carbamoyl-2-phenyl-ethylamino)-butyric acid tert-butyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / N,N'-dicyclohexylcarbodiimide (DCC), N,N-diisopropylethylamine (DIEA), 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

2: AlLiH₄ / tetrahydrofuran; diethyl ether / 1 h / 0 °C

3: 60 percent / sodium cyanoborohydride / methanol; acetic acid / 3 h

4: H₂, HCl / 10 percent Pd/C / ethanol / 4 h

With hydrogenchloride; dmap; lithium aluminium tetrahydride; hydrogen; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00150a020