4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1026637-41-1
• Molecular Formula: C₁₈H₂₈N₂O₄
• Molecular Weight: 336.431
• Mol file: 1026637-41-1.mol

Synonyms:4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + (2-amino-3-methoxyphenyl)methanol (205877-13-0) → 4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (1026637-41-1)

Guidance literature:

N-tert-butyloxycarbonylpiperidin-4-one; (2-amino-3-methoxyphenyl)methanol; With acetic acid; In toluene; for 6h; Heating;

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; toluene; at 20 ℃; for 24h;

DOI:10.1021/jm049599u

Reference yield:

2-amino-3-methoxybenzoic acid (3177-80-8) → 4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (1026637-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 88 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

2.1: acetic acid / toluene / 6 h / Heating

2.2: NaBH₃CN; acetic acid / toluene; tetrahydrofuran / 24 h / 20 °C

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; toluene;

DOI:10.1021/jm049599u

Reference yield:

4-(2-hydroxymethyl-6-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (1026637-41-1) → N-[4-(ethylphenylamino)phenyl]-2-[4-(8-methoxy-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)piperidin-1-yl]acetamide

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine / tetrahydrofuran / 73 h / 0 - 20 °C

2: HCl / diethyl ether; ethyl acetate / 4 h / 0 °C

3: K₂CO₃ / dimethylformamide / 20 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm049599u

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

(2-amino-3-methoxyphenyl)methanol

2-amino-3-methoxybenzoic acid