205877-13-0Relevant articles and documents
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine
Wikstr?m, H?kan V.,Mensonides-Harsema, Marguérite M.,Cremers, Thomas I. F. H.,Moltzen, Ejner K.,Arnt, J?rn
, p. 3280 - 3285 (2002)
The synthesis and resolution of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methy[dibenzo[c,f]pyrazino [1,2-α]azepin (6-methoxymianserin, 6) are described. Furthermore, the in vitro and in vivo effects of 6 and its enantiomers are presented. 6 displayed high aff
Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Br?nsted acid
Li, Jianjun,Fu, Yiwei,Qin, Cong,Yu, Yang,Li, Hao,Wang, Wei
supporting information, p. 6474 - 6477 (2017/08/16)
A catalytic asymmetric method for the synthesis of chiral isoquinolinonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-aldehydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.
The role of methoxy substituents in regulating the activity of selenides that serve as spirodioxyselenurane precursors and glutathione peroxidase mimetics
Press, David J.,Back, Thomas G.
, p. 305 - 311 (2016/04/20)
A series of o-(hydroxymethyl)phenyl selenides containing single or multiple methoxy substituents was synthesized, and the rate at which each compound catalyzed the oxidation of benzyl thiol to its disulfide with excess hydrogen peroxide was measured. This