Technology Process of C47H56O3Si
There total 5 articles about C47H56O3Si which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl-pent-4-ynyloxy-diphenyl-silane;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
(17S)-spiro[3-benzyloxyestra-1,3,5(10)-trien-17,2'-oxirane];
With
boron trifluoride diethyl etherate;
In
tetrahydrofuran;
at -78 ℃;
for 5h;
Inert atmosphere;
With
water; ammonium chloride;
In
tetrahydrofuran;
DOI:10.1021/ol2017966
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / tetrahydrofuran / 8 h / Inert atmosphere; Reflux
2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 2 h / 20 °C / Inert atmosphere
2.2: 12 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
3.2: 5 h / -78 °C / Inert atmosphere
With
n-butyllithium; sodium hydride; caesium carbonate;
In
tetrahydrofuran; dimethyl sulfoxide; mineral oil;
DOI:10.1021/ol2017966
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 2 h / 20 °C / Inert atmosphere
1.2: 12 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 5 h / -78 °C / Inert atmosphere
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; dimethyl sulfoxide; mineral oil;
DOI:10.1021/ol2017966
