68687-35-4Relevant academic research and scientific papers
Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
Romero-Hernández, Laura L.,Merino-Montiel, Penélope,Meza-Reyes, Socorro,Vega-Baez, José Luis,López, óscar,Padrón, José M.,Montiel-Smith, Sara
, p. 21 - 32 (2018)
Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and estrone, decorated with spiranic oxazolidin-2-one or 2-aminooxazoline motifs at C-17 as potential antiproliferative agents. Such unp
Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging
Barbeau, Xavier,Lambert, Jean-Philippe,Ngueta Djiemeny, Adrien,Poirier, Donald,Roy, Jenny,Maltais, René
, (2020/03/05)
Steroid sulfatase (STS) is an important enzyme regulating the conversion of sulfated steroids into their active hydroxylated forms. Notably, the inhibition of STS has been shown to decrease the levels of active estrogens and was translated into clinical t
Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of hedgehog signaling based on cyclopamine
Zhang, Zhihui,Baubet, Valerie,Ventocilla, Christian,Xiang, Chaomei,Dahmane, Nadia,Winkler, Jeffrey D.
, p. 4786 - 4789 (2011/11/12)
Previous work in this laboratory established that the readily available F-ring aromatic analog of cyclopamine is a highly potent inhibitor of Hedgehog signaling. The synthesis and biological evaluation of two F-ring saturated analogs that are more potent
