5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

Base Information

Chemical Name:5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde
CAS No.:1228102-81-5
Molecular Formula:C₂₅H₁₉N₃O₃S₂
Molecular Weight:473.576
Hs Code.:

Synonyms:5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

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Chemical Property of 5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

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Technology Process of 5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

There total 11 articles about 5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1228102-80-4
6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

: 1228102-81-5
5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

Guidance literature:: With toluene-4-sulfonic acid; acetone; at 20 ℃; for 20h;

Reference yield:

: 131770-85-9
3-[(4-methoxybenzyl)oxy]aniline

: 1228102-81-5
5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

3: toluene-4-sulfonic acid; acetone / 20 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; toluene-4-sulfonic acid; acetone; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 2: |Suzuki Coupling;

Reference yield:

: 1-(4-methoxybenzyloxy)-3-nitrobenzene

: 1228102-81-5
5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: iron; water / methanol / 15 h / Reflux

2: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

4: toluene-4-sulfonic acid; acetone / 20 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; iron; sodium carbonate; toluene-4-sulfonic acid; acetone; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3: |Suzuki Coupling;