N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine

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Chemical Name:N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine
CAS No.:1228103-15-8
Molecular Formula:C₂₉H₂₈N₄O₂S₂
Molecular Weight:528.699
Hs Code.:

Synonyms:N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine

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Chemical Property of N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine

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Technology Process of N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine

There total 12 articles about N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

: 123-75-1
pyrrolidine

: 1228102-81-5
5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde

: 1228103-15-8
N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: pyrrolidine; 5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde; In 1,2-dichloro-ethane; for 0.333333h;

With sodium acetate; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 7h;

Reference yield:

: 1-(4-methoxybenzyloxy)-3-nitrobenzene

: 1228103-15-8
N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; water / methanol / 15 h / Reflux

2.1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid; acetone / 20 h / 20 °C

5.1: 1,2-dichloro-ethane / 0.33 h

5.2: 7 h / 20 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; iron; sodium carbonate; toluene-4-sulfonic acid; acetone; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3.1: |Suzuki Coupling;

Reference yield:

: 1228102-80-4
6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

: 1228103-15-8
N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid; acetone / 20 h / 20 °C

2.1: 1,2-dichloro-ethane / 0.33 h

2.2: 7 h / 20 °C

With toluene-4-sulfonic acid; acetone; In 1,2-dichloro-ethane;