6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

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Chemical Name:6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine
CAS No.:1228102-80-4
Molecular Formula:C₂₇H₂₃N₃O₄S₂
Molecular Weight:517.629
Hs Code.:

Synonyms:6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

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Chemical Property of 6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

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Technology Process of 6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

There total 10 articles about 6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1351353-50-8
2-(5-(1,3-dioxolan-2-yl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1228102-67-7
6-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

: 1228102-80-4
6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 15h; Inert atmosphere;

Reference yield:

: 131770-85-9
3-[(4-methoxybenzyl)oxy]aniline

: 1228102-80-4
6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 2: |Suzuki Coupling;

Reference yield:

: 1-(4-methoxybenzyloxy)-3-nitrobenzene

: 1228102-80-4
6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: iron; water / methanol / 15 h / Reflux

2: 1,2-dichloro-ethane; tert-butyl alcohol / 72 h / 85 °C / Sealed tube

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / N,N-dimethyl-formamide / 15 h / 80 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; iron; sodium carbonate; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol; 3: |Suzuki Coupling;