1-(2-Methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline

Base Information

• Chemical Name: 1-(2-Methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline
• CAS No.: 122456-37-5
• Molecular Formula: C20H21 N3
• Molecular Weight: 303.407
• DSSTox Substance ID: DTXSID20153623
• Nikkaji Number: J474.806I
• Wikidata: Q83020581
• ChEMBL ID: CHEMBL54511
• Mol file: 122456-37-5.mol

Synonyms:1-(2-methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline;1-MDPQ;SK and F 96356;SK and F-96356;SKF 96356

Chemical Property of 1-(2-Methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline

Chemical Property:

• Vapor Pressure: 1.64E-10mmHg at 25°C
• Boiling Point: 509.8°Cat760mmHg
• Flash Point: 262.1°C
• PSA: 31.39000
• Density: 1.198g/cm³
• LogP: 4.07440
• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 303.173547683
• Heavy Atom Count: 23
• Complexity: 412

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=CC=C1)C3=C(CCN3C4=CC=CC=C4C)C(=N2)NC

Technology Process of 1-(2-Methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline

There total 4 articles about 1-(2-Methylphenyl)-4-methylamino-6-methyl-2,3-dihydropyrrolo(3,2-c)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-(2-methylphenyl)-4-chloro-6-methyl-2,3-dihydropyrrolo<3.2-c>quinoline (122456-58-0) → 1-(2-methylphenyl)-4-(methylamino)-6-methyl-2,3-dihydropyrrolo<3,2-c>quinoline (122456-37-5)

Guidance literature:

With methylamine; In ethanol;

Reference yield: 71.0%

1-(2-methylphenyl)-4-chloro-6-methyl-2,3-dihydropyrrolo<3.2-c>quinoline (122456-58-0) + methylamine (74-89-5) → 1-(2-methylphenyl)-4-(methylamino)-6-methyl-2,3-dihydropyrrolo<3,2-c>quinoline (122456-37-5)

Guidance literature:

In ethanol; at 180 ℃; for 24h;

DOI:10.1021/jm00088a021

Reference yield:

diethyl 2-ethoxyethylmalonate (13487-89-3) → 1-(2-methylphenyl)-4-(methylamino)-6-methyl-2,3-dihydropyrrolo<3,2-c>quinoline (122456-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 237 g / 5 h / 195 °C

2: 2.) phosphoryl chloride / 1.) diphenyl ether, reflux, 7 h, 2.) reflux, 1.5 h

3: 71 percent / ethanol / 24 h / 180 °C

With trichlorophosphate; In ethanol;

DOI:10.1021/jm00088a021

upstream raw materials:

1-(2-methylphenyl)-4-chloro-6-methyl-2,3-dihydropyrrolo<3.2-c>quinoline

methylamine

diethyl 2-ethoxyethylmalonate

2-(2-ethoxyethyl)-N,N'-bis(2-methylphenyl)malonodiamide

Refernces

• 1、 -. "DIHYDROPYRROLO QUINOLINE DERIVATIVES". . . Retrieved 2008/06/13.