oxazolam

Base Information

• Chemical Name: oxazolam
• CAS No.: 29912-93-4
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.798
• Mol file: 29912-93-4.mol

Synonyms:oxazolam

Chemical Property of oxazolam

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of oxazolam

There total 4 articles about oxazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-bromoacetamido)-5-chloro-benzophenone (32580-26-0) + base 5-chloro-2[ 1-hydroxy-2-propylamino)acetamido]benzophenone + dl-2-amino-1-propanol hydrochloride (6170-23-6,17016-92-1) → oxazolam (29912-93-4)

Guidance literature:

With hydrogenchloride; triethylamine; In pyridine; ethanol; hexane; ethyl acetate;

Reference yield:

2-Amino-1-propanol (6168-72-5) + 2-(2-bromoacetamido)-5-chloro-benzophenone (32580-26-0) → oxazolam (29912-93-4)

Guidance literature:

Multistep reaction; (i) CH₂Cl₂, (ii) AcOH, EtOH;

DOI:10.1021/jm00288a015

Reference yield:

7-Chloro-4-(2-hydroxy-1-methyl-ethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium → oxazolam (29912-93-4)

Guidance literature:

In ethanol; water; at 25 ℃; Rate constant;

DOI:10.1248/cpb.35.3831

upstream raw materials:

2-Amino-1-propanol

2-(2-bromoacetamido)-5-chloro-benzophenone

dl-2-amino-1-propanol hydrochloride

Downstream raw materials:

2-(4b-hydroxyisopropylamino)acetanilide-5-chlorobenzophenone

10-chloro-3,7-dimethyl-11b-phenyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one