5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine
• CAS No.: 193894-17-6
• Molecular Formula: C₄₇H₆₀N₆O₁₂SSi
• Molecular Weight: 961.178
• Mol file: 193894-17-6.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine

There total 10 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine (143526-94-7,139063-29-9) + 4-nitrophenyl 3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine-3'-sulfamate (428506-21-2) → 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine (193894-17-6)

Guidance literature:

With 4 A molecular sieve; In dichloromethane; for 12h;

DOI:10.1039/b110603c

Reference yield: 68.0%

5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine (130128-70-0) + [(2S,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-sulfamic acid 2-hydroxy-phenyl ester (193894-15-4) → 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine (193894-17-6)

Guidance literature:

In 1,4-dioxane; for 2h; Heating;

DOI:10.1016/S0040-4039(97)01179-9 DOI:10.1016/S0040-4020(97)10421-5

Reference yield: 56.0%

3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine (143526-94-7,139063-29-9) + [(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester (193894-18-7) → 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine (193894-17-6)

Guidance literature:

In 1,4-dioxane; for 4h; Heating;

DOI:10.1016/S0040-4039(97)01179-9 DOI:10.1016/S0040-4020(97)10421-5

upstream raw materials:

3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine

[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-sulfamic acid 2-hydroxy-phenyl ester

5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine

[(2S,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-sulfamic acid 2-hydroxy-phenyl ester

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine