193894-15-4

Upstream product

• 4074-55-9 1,3,2-benzdioxathiole-2,2-dioxide 
• 130128-70-0 5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine 
• 126441-74-5 3’-azido-5’-O-(4,4’-dimethoxytrityl)-3’-deoxythymidine 
• 143526-94-7 3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine 

Downstream Products

• 193894-21-2 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine 
• 193894-17-6 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine 

Relevant academic research and scientific papers

Sulfamide replacement of the phosphodiester linkage in dinucleotides: Synthesis and conformational analysis

Dinucleotide analogues d(TnsnT) and d(TnsnA), in which the phosphodiester linkage of d(TpT) and d(TpA) is replaced by sulfamide [-NHSO2NH-], have been synthesised. Conformational analysis using 3J vicinal coupling constants shows that this modification results in a shift from a predominantly southern (C2'-endo) to northern (C3'-endo) ribose ring conformation. The effect of temperature and concentration changes on ribose conformation, reveals that the modified dinucleosides have a greater propensity to base stack intramolecularly, and in the case d(TnsnA), self-associate.

Synthesis of sulfamide linked dinucleotide analogues

Novel sulfamide [-NHSO2NH-] linked dinucleotide analogues d(TnsnT) and d(TnsnA) have been synthesised from 3'- and 5'-amino nucleosides. Treatment of these amino nucleosides with catechol sulfate results in the formation of 2-hydroxyphenyl sulf