3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol

Base Information

• Chemical Name: 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol
• CAS No.: 960249-81-4
• Molecular Formula: C₁₃H₁₉F₃N₂O
• Molecular Weight: 276.302
• Mol file: 960249-81-4.mol

Synonyms:3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol

Chemical Property of 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol

There total 1 articles about 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-(trifluoromethyl)-2-oxiranyl]methyl 4-methylbenzenesulfonate (960249-70-1) + N-ethylbenzylamine (14321-27-8) → 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol (960249-81-4)

Guidance literature:

[2-(trifluoromethyl)-2-oxiranyl]methyl 4-methylbenzenesulfonate; N-ethylbenzylamine; In 1,4-dioxane; at 21 ℃; for 24h;

With ammonia; In 1,4-dioxane; at 21 - 100 ℃; for 24.5h;

Reference yield: 66.0%

5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid (187949-90-2) + 3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol (960249-81-4) → 5-amino-N-(2-{[ethyl(phenylmethyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide (960249-82-5)

Guidance literature:

With HATU; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2016.08.091

Reference yield:

3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol (960249-81-4) → 5-amino-N-(2-{[ethyl(phenylmethyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide (960249-82-5)

Guidance literature:

5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

3-amino-2-{[ethyl(phenylmethyl)amino]methyl}-1,1,1-trifluoro-2-propanol; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

upstream raw materials:

[2-(trifluoromethyl)-2-oxiranyl]methyl 4-methylbenzenesulfonate

N-ethylbenzylamine

Downstream raw materials:

5-amino-N-(2-{[ethyl(phenylmethyl)amino]methyl}-3,3,3-trifluoro-2-hydroxypropyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide

5-amino-N-{2-[(ethylamino)methyl]-3,3,3-trifluoro-2-hydroxypropyl}-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide