4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester
CAS No.:191226-91-2
Molecular Formula:C₂₃H₂₆BrNO₅
Molecular Weight:476.367
Hs Code.:

4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid <i>tert</i>-butyl ester

Synonyms:4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

Suppliers and Price of 4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

There total 4 articles about 4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 143601-45-0
(S)-tert-butyl 4-<(benzyloxycarbonyl)amino>-3-oxo-5-phenylpentanoate

: 191226-91-2
4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

: 4-benzyloxycarbonylamino-2,2-dibromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

Guidance literature:: With 2,6-dimethylpyridine; N-Bromosuccinimide; In methanol; at 20 ℃; for 2.5h;
DOI:10.1021/jo010319h

Reference yield:

: 143601-45-0
(S)-tert-butyl 4-<(benzyloxycarbonyl)amino>-3-oxo-5-phenylpentanoate

: 191226-91-2
4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

Guidance literature:: With bromine; calcium carbonate; In dichloromethane; at -10 ℃; for 2h;
DOI:10.1021/ol017163s

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 191226-91-2
4-benzyloxycarbonylamino-2-bromo-3-oxo-5-phenyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -45 °C

1.2: 96.6 percent / tetrahydrofuran / 1 h / -50 °C

2.1: 93 percent Chromat_. / bromine; calcium carbonate / CH₂Cl₂ / 2 h / -10 °C

With bromine; calcium carbonate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.2: cross-Claisen condensation;
DOI:10.1021/ol017163s