(3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

Base Information

Chemical Name:(3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril
CAS No.:90664-05-4
Molecular Formula:C₁₄H₁₇NO
Molecular Weight:215.295
Hs Code.:

Synonyms:(3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

Suppliers and Price of (3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

There total 8 articles about (3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 143-33-9,25596-52-5
sodium cyanide

: 90664-04-3
(2R,3R,4E)-(-)-(3-Methoxy-2-methyl-5-phenyl-4-pentenyl)-p-toluolsulfonat

: 90664-05-4
(3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

Guidance literature:: In N,N-dimethyl-formamide; at 115 ℃; for 0.666667h;

Reference yield:

: 70633-77-1
(3S,4E)-(+)-3-Hydroxy-5-phenyl-4-pentensaeure-methylester

: 90664-05-4
(3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

Guidance literature:: Multi-step reaction with 7 steps

1: 1) lithiumdiisopropylamide / 1) THF, 2 h, -78 deg C, 2) -78 deg C to RT

2: 83 percent / LiAlH₄ / diethyl ether / 0.08 h / Heating

3: 100 percent / imidazole / dimethylformamide / 1 h / 0 °C

4: 100 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

5: 90 percent / tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 2.5 h / Ambient temperature

6: 90 percent / pyridine / CH₂Cl₂ / 18 h / Ambient temperature

7: 96 percent / dimethylformamide / 0.67 h / 115 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 86853-07-8
(2S,3R,4E)-(+)-3-Hydroxy-2-methyl-5-phenyl-4-pentensaeure-methylester

: 90664-05-4
(3R,4S,5E)-(+)-4-Methoxy-3-methyl-6-phenyl-5-hexennitril

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / LiAlH₄ / diethyl ether / 0.08 h / Heating

2: 100 percent / imidazole / dimethylformamide / 1 h / 0 °C

3: 100 percent / NaH / tetrahydrofuran / 1 h / Ambient temperature

4: 90 percent / tetra-n-butylammoniumfluoride trihydrate / tetrahydrofuran / 2.5 h / Ambient temperature

5: 90 percent / pyridine / CH₂Cl₂ / 18 h / Ambient temperature

6: 96 percent / dimethylformamide / 0.67 h / 115 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;