ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate

Base Information

• Chemical Name: ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate
• CAS No.: 250601-62-8
• Molecular Formula: C₂₉H₂₉N₃O₅
• Molecular Weight: 499.566
• Mol file: 250601-62-8.mol

Synonyms:ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate

Chemical Property of ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate

There total 8 articles about ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl γ-oxo-2-pyridinebutanoate (26749-23-5) + 4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyamine (250602-85-8) → ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate (250601-62-8)

Guidance literature:

With sodium acetate; acetic acid; In ethanol; for 12h; Heating;

DOI:10.1248/cpb.51.138

Reference yield:

4-{[4-(chloromethyl)phenoxy]methyl}-5-methyl-2-phenyl-1,3-oxazole (250602-53-0) → ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate (250601-62-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 20 h / 20 °C

2: 90 percent / hydrazine monohydrate / ethanol; tetrahydrofuran / 3 h / Heating

3: 75 percent / acetic acid; sodium acetate / ethanol / 12 h / Heating

With sodium acetate; potassium carbonate; hydrazine hydrate; acetic acid; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.51.138

Reference yield:

N-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxy}phtalimide (250602-81-4) → ethyl (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-(2-pyridyl)butyrate (250601-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydrazine monohydrate / ethanol; tetrahydrofuran / 3 h / Heating

2: 75 percent / acetic acid; sodium acetate / ethanol / 12 h / Heating

With sodium acetate; hydrazine hydrate; acetic acid; In tetrahydrofuran; ethanol;

DOI:10.1248/cpb.51.138

upstream raw materials:

ethyl γ-oxo-2-pyridinebutanoate

4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyamine

2-Picolinic acid

t-butyl 3-oxo-3-(2-pyridyl)propanoate