C₂₄H₃₃FN₄O₂S

Base Information

Chemical Name:C₂₄H₃₃FN₄O₂S
CAS No.:1414397-22-0
Molecular Formula:C₂₄H₃₃FN₄O₂S
Molecular Weight:460.616
Hs Code.:

C<sub>24</sub>H<sub>33</sub>FN<sub>4</sub>O<sub>2</sub>S

Synonyms:C₂₄H₃₃FN₄O₂S

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₄H₃₃FN₄O₂S

Chemical Property:

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Technology Process of C₂₄H₃₃FN₄O₂S

There total 7 articles about C₂₄H₃₃FN₄O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414360-80-7
3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide

: 1414397-22-0
C₂₄H₃₃FN₄O₂S

Guidance literature:: 3-[2-fluoro-5-[[4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]propanamide; With bis-[(trifluoroacetoxy)iodo]benzene; In acetonitrile; at 10 - 20 ℃; for 2.33333h;

With sulfuric acid; In water; acetonitrile; for 1h;

With sodium hydroxide; In water;

Reference yield:

: 1179336-71-0
tert-butyl 4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

: 1414397-22-0
C₂₄H₃₃FN₄O₂S

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

2.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichlorobis(tri-O-tolylphosphine)palladium / acetonitrile / 16 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 3375.34 Torr

5.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile / 2.33 h / 10 - 20 °C

5.2: 1 h

With hydrogenchloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; bis-[(trifluoroacetoxy)iodo]benzene; dichlorobis(tri-O-tolylphosphine)palladium; palladium 10% on activated carbon; In 2-methyltetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; acetonitrile; 3.1: Heck Reaction;

Reference yield:

: tert-butyl 7-oxa-3,10-diazaspiro[5.5]undecane-3-carboxylate hydrochloride

: 1414397-22-0
C₂₄H₃₃FN₄O₂S

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran; 2-methyltetrahydrofuran / 1 h / 5 - 20 °C / Industry scale

2.1: hydrogenchloride; isopropyl alcohol / tert-butyl methyl ether; 2-methyltetrahydrofuran / 28 h / 20 - 40 °C / Industry scale

3.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichlorobis(tri-O-tolylphosphine)palladium / acetonitrile / 16 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 3375.34 Torr

6.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile / 2.33 h / 10 - 20 °C

6.2: 1 h

With hydrogenchloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; bis-[(trifluoroacetoxy)iodo]benzene; dichlorobis(tri-O-tolylphosphine)palladium; palladium 10% on activated carbon; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; acetonitrile; 4.1: Heck Reaction;