N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide

Base Information

• Chemical Name: N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide
• CAS No.: 1333127-16-4
• Molecular Formula: C₂₇H₂₁Cl₂F₆N₅O₅
• Molecular Weight: 680.391
• Mol file: 1333127-16-4.mol

Synonyms:N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide

Chemical Property of N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide

There total 7 articles about N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3-(trifluoroacetylamino)propoxy]-4-[trifluoroacetyl-(methyl)amino]benzoic acid (1333127-11-9) + 2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide (229343-30-0) → N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide (1333127-16-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 48h;

Reference yield:

4-Aminosalicylic acid (65-49-6) → N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide (1333127-16-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 24 h

2.1: potassium carbonate / 1 h / 110 °C

3.1: hydrogenchloride / ethanol; water / 2 h

4.1: zinc; sodium hydroxide / water / 4 h / 60 °C

4.2: pH 4 - 5

5.1: sodium hydroxide; water / ethanol / 10 h / 100 °C / Sealed ampoule

5.2: pH 8 - 9

6.1: 1 h

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid (184033-42-9) → N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)-propoxy)phenylcarbonylamino]-5-chlorobenzamide (1333127-16-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / 1 h / 110 °C

2.1: hydrogenchloride / ethanol; water / 2 h

3.1: zinc; sodium hydroxide / water / 4 h / 60 °C

3.2: pH 4 - 5

4.1: sodium hydroxide; water / ethanol / 10 h / 100 °C / Sealed ampoule

4.2: pH 8 - 9

5.1: 1 h

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In tetrahydrofuran; ethanol; water;

upstream raw materials:

2-[3-(trifluoroacetylamino)propoxy]-4-[trifluoroacetyl-(methyl)amino]benzoic acid

2-amino-5-chloro-N-(5-chloro-pyridin-2-yl)-benzamide

4-Aminosalicylic acid

4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid

Downstream raw materials:

N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)phenylcarbonylamino]-5-chlorobenzamide

N-(5-chloropyridine-2-yl)-2-[4-(ethaneimidoylmethylamino)-2-(3-aminopropoxy)phenylcarbonylamino]-5-chlorobenzamide