(1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane
CAS No.:1076206-66-0
Molecular Formula:C₁₂H₁₃F₃N₂
Molecular Weight:242.244
Hs Code.:

Synonyms:(1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Suppliers and Price of (1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

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Chemical Property of (1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

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Technology Process of (1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

There total 11 articles about (1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076206-64-8
(1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

: 1076206-66-0
(1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: With hydrogen bromide; acetic acid; at 80 ℃; for 2h;

Reference yield:

: 142928-26-5
(2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<(3,5-dimethyl-1H-pyrazol-1-yl)-carbonyl>pyrrolidine

: 1076206-66-0
(1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / -40 °C

2.2: -40 - 20 °C

3.1: hydrogenchloride; ethanol; water / 5 h / 20 °C

4.1: pyridine / 92 h / 0 - 20 °C

5.1: toluene / 156 h / Heating / reflux

6.1: hydrogen bromide; acetic acid / 2 h / 80 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; ethanol; water; hydrogen bromide; acetic acid; In tetrahydrofuran; toluene;

Reference yield:

: 1076206-60-4
(2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol

: 1076206-66-0
(1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; ethanol; water / 5 h / 20 °C

2: pyridine / 92 h / 0 - 20 °C

3: toluene / 156 h / Heating / reflux

4: hydrogen bromide; acetic acid / 2 h / 80 °C

With pyridine; hydrogenchloride; ethanol; water; hydrogen bromide; acetic acid; In toluene;